550 5.1.10 is a permanent SMTP reply meaning recipient not found (microsoft 365 / outlook). Microsoft explains that the SMTP address lookup did not find the recipient. For @outlook.com and @hotmail.com addresses the same problem can appear as 550 5.5.0 "Requested action not taken: mailbox unavailable".
What 550 5.1.10 means
Microsoft explains that the SMTP address lookup did not find the recipient. For @outlook.com and @hotmail.com addresses the same problem can appear as 550 5.5.0 "Requested action not taken: mailbox unavailable".
Common causes
The address is wrong or no longer exists
Most commonA typo, or a person who left the company and whose mailbox was removed.
Your list has old or guessed addresses
CommonPattern-guessed or bought lists produce many 5.1.10 bounces at once, which also hurts your sender reputation.
The recipient domain moved to Microsoft 365 but the user was not set up
Less commonThe domain points its MX at Microsoft, but this address was not created there.
How to fix 550 5.1.10
- 1
Check the exact address
Confirm the spelling with the recipient, or find a current address another way.
- 2
Remove the address from your list
Do not retry. Suppress it so you do not send to it again.
- 3
Verify lists before large sends
A high rate of 5.1.10 bounces is a reputation problem. Verify addresses before a campaign, especially guessed ones.
Confirm your domain is set up correctly
Most delivery failures — permanent or temporary — trace back to authentication or reputation. Run a free EmailHealth check to confirm SPF, DKIM, DMARC, blacklist status, and TLS are all healthy for your sending domain. If you send in volume, free daily monitoring will alert you before a small issue becomes a flood of bounces.